abstract：:Neurobehavioral deficits have been reported in Egyptian pesticide application teams using organophosphorus (OP) pesticides, but whether these effects are related to OP pesticide exposures has yet to be established. In preparation for a comprehensive study of the relationship between OP pesticide dose and neurobehavior...

journal_title：Neurotoxicology

authors： Farahat FM,Fenske RA,Olson JR,Galvin K,Bonner MR,Rohlman DS,Farahat TM,Lein PJ,Anger WK

更新日期：2010-06-01 00:00:00

abstract：:Identification of critical receptors in seizure controlling brain regions may facilitate the development of more efficacious pharmacological therapies against nerve agent intoxication. In the present study, a number of drugs with anticonvulsant potency were microinfused into the perirhinal cortex (PRC) or posterior pi...

journal_title：Neurotoxicology

authors： Myhrer T,Enger S,Aas P

更新日期：2010-01-01 00:00:00

abstract：:The chemosensory effects of propionic acid (PA) in humans have not been conclusively studied and there is no established occupational exposure limit (OEL) in Germany. In addition to sensory irritation caused by PA, it was hypothesized that the annoying odor of PA might interfere with the performance results. There wer...

journal_title：Neurotoxicology

authors： Hey K,Juran S,Schäper M,Kleinbeck S,Kiesswetter E,Blaszkewicz M,Golka K,Brüning T,van Thriel C

更新日期：2009-11-01 00:00:00

abstract：:Previous investigations have presented evidence for an increased prevalence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if there was a correlation between mercury exposure and cognitive effects in a Norwegian population of dental workers, and if so, to quantify the o...

journal_title：Neurotoxicology

authors： Hilt B,Svendsen K,Syversen T,Aas O,Qvenild T,Sletvold H,Melø I

更新日期：2009-11-01 00:00:00

abstract：:Exposure to neurotoxic agents represents a concern of high priority in modern society. The nervous system can compensate for the toxic effects caused by low doses, but prolonged and lifetime exposure can also lead to delayed neurodegenerative effects for very low levels. The reported frequency of neurodegenerative dis...

journal_title：Neurotoxicology

authors： Lucchini R,Zimmerman N

更新日期：2009-11-01 00:00:00

abstract：:A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...

journal_title：Neurotoxicology

authors： Manning-Boğ AB,Schüle B,Langston JW

更新日期：2009-11-01 00:00:00

abstract：:Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease is also characterized by an increase in oxidative stress and a loss of glutathione in the midbrain region. A potential link between all these factors is the ox...

journal_title：Neurotoxicology

authors： Linsenbardt AJ,Wilken GH,Westfall TC,Macarthur H

更新日期：2009-11-01 00:00:00

abstract：:Recent findings derived from large-scale datasets and biobanks link multiple genes to autism spectrum disorders. Consequently, novel rodent mutants with deletions, truncations and in some cases, overexpression of these candidate genes have been developed and studied both behaviorally and biologically. At the Annual Ne...

journal_title：Neurotoxicology

authors： Halladay AK,Amaral D,Aschner M,Bolivar VJ,Bowman A,DiCicco-Bloom E,Hyman SL,Keller F,Lein P,Pessah I,Restifo L,Threadgill DW

更新日期：2009-09-01 00:00:00

abstract：:The review aimed at quantifying the evidence of performance effects resulting from occupational exposure to manganese. Epidemiological studies published between 1987 and 2008 were analyzed. The approach was based on the meta-analytical method of effect size estimates and sought to contribute to the following issues: (...

journal_title：Neurotoxicology

authors： Meyer-Baron M,Knapp G,Schäper M,van Thriel C

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...

journal_title：Neurotoxicology

authors： Van Calsteren K,Hartmann D,Van Aerschot L,Verbesselt R,Van Bree R,D'Hooge R,Amant F

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment. However, little is known about the potential association between environmental levels of Pb and Mn on intelligence of children. The aims of the study were to investigate the asso...

journal_title：Neurotoxicology

authors： Kim Y,Kim BN,Hong YC,Shin MS,Yoo HJ,Kim JW,Bhang SY,Cho SC

更新日期：2009-07-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a principal site for protein synthesis, protein folding, calcium storage, and calcium signaling. Thapsigargin (TG), an inducer of ER stress, inhibits ER-associated Ca(2+)-ATPase and disrupts Ca(2+) homeostasis. ER stress plays an important pathogenetic role in Alzheimer's disease, Par...

journal_title：Neurotoxicology

authors： Sohn SH,Ko E,Jeon SB,Lee BJ,Kim SH,Dong MS,Lee DU,Kwak JH,Kim Y,Shin M,Hong M,Bae H

更新日期：2009-05-01 00:00:00

abstract：:Olfactory transport of represents an important mechanism for direct delivery of certain metals to the central nervous system (CNS). The objective of this study was to determine whether inhaled tungsten (W) undergoes olfactory uptake and transport to the rat brain. Male, 16-week-old, Sprague-Dawley rats underwent a sin...

journal_title：Neurotoxicology

authors： Radcliffe PM,Olabisi AO,Wagner DJ,Leavens T,Wong BA,Struve MF,Chapman GD,Wilfong ER,Dorman DC

更新日期：2009-05-01 00:00:00

abstract：:The developing female brain represents a potential target for estrogenic environmental chemicals because it depends on estrogen but is exposed to low endogenous estrogen levels, thus facilitating competition by exogenous estrogen receptor (ER) agonists. We investigated effects of two estrogenic UV filters, 4-methylben...

journal_title：Neurotoxicology

authors： Faass O,Schlumpf M,Reolon S,Henseler M,Maerkel K,Durrer S,Lichtensteiger W

更新日期：2009-03-01 00:00:00

abstract：:Gadolinium is a rare-earth lanthanide metal ion and is used as organic gadolinium complexes in magnetic resonance imaging (MRI). Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney ...

journal_title：Neurotoxicology

authors： Ishibashi H,Hirao K,Yamaguchi J,Nabekura J

更新日期：2009-01-01 00:00:00

abstract：:Human neuroblastoma SH-SY5Y is a dopaminergic neuronal cell line which has been used as an in vitro model for neurotoxicity experiments. Although the neuroblastoma is usually differentiated by all-trans-retinoic acid (RA), both RA-differentiated and undifferentiated SH-SY5Y cells have been used in neuroscience researc...

journal_title：Neurotoxicology

authors： Cheung YT,Lau WK,Yu MS,Lai CS,Yeung SC,So KF,Chang RC

更新日期：2009-01-01 00:00:00

abstract：:Synaptic dysfunction appears to be an early pathogenic event in Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. Although the molecular mechanism of this synaptotoxicity is not known, evidence suggests that these diseases are characterized by a common pathophysiological cascade involving oxi...

journal_title：Neurotoxicology

authors： Lopachin RM,Gavin T,Barber DS

更新日期：2008-09-01 00:00:00

abstract：:Neurotoxicology is entering a new phase in how it views and practices risk assessment. Perhaps more than any of the other disciplines that comprise the science of toxicology, it has been compelled to consider a daunting array of factors other than those directly coupled to chemical and dose, and the age and sex of the...

journal_title：Neurotoxicology

authors： Weiss B,Cory-Slechta D,Gilbert SG,Mergler D,Miller E,Miller C,Newland MC,Rice D,Schettler T

更新日期：2008-09-01 00:00:00

abstract：:Selenium (Se) supplementation in the nutritionally relevant range counteracts methylmercury (MeHg) toxicity. Since Se tends to be abundant in fish, MeHg exposures alone may not provide an accurate index of risk from fish consumption. Molar ratios of MeHg:Se in the diets and Hg:Se in tissues of exposed individuals may ...

journal_title：Neurotoxicology

authors： Ralston NV,Ralston CR,Blackwell JL 3rd,Raymond LJ

更新日期：2008-09-01 00:00:00

abstract：:Effects of d-amphetamine on the renal outer medullary potassium (ROMK1) channels were tested in the Xenopus oocytes expression system. Xenopus oocytes were injected with mRNA coding for wild-type or mutant ROMK1 channels. Giant inside-out patch-clamp recordings were performed. d-Amphetamine inhibited the activity of R...

journal_title：Neurotoxicology

authors： Lee CH,Liou HH,Lu KL,Shen YC,Tsai MC

更新日期：2008-07-01 00:00:00

abstract：:The field of neurotoxicology needs to satisfy two opposing demands: the testing of a growing list of chemicals, and resource limitations and ethical concerns associated with testing using traditional mammalian species. National and international government agencies have defined a need to reduce, refine or replace mamm...

journal_title：Neurotoxicology

authors： Peterson RT,Nass R,Boyd WA,Freedman JH,Dong K,Narahashi T

更新日期：2008-05-01 00:00:00

abstract：:Prediction of neurotoxic effects is a key feature in the toxicological profile of many compounds and therefore is required by regulatory testing schemes. Nowadays neurotoxicity assessment required by the OECD and EC test guidelines is based solely on in vivo testing, evaluating mainly effects on neurobehavior and neur...

journal_title：Neurotoxicology

authors： Bal-Price AK,Suñol C,Weiss DG,van Vliet E,Westerink RH,Costa LG

更新日期：2008-05-01 00:00:00

abstract：:Cytoskeletal alteration is a key factor in neurodegenerative processes like Alzheimer's or Parkinson's disease. Colchicine is a microtubule-disrupting agent that binds to tubuline, inhibiting microtubule assembly, and which triggers apoptosis. The present research describes the transcriptional activation of molecules ...

journal_title：Neurotoxicology

authors： Yeste-Velasco M,Alvira D,Sureda FX,Rimbau V,Forsby A,Pallàs M,Camins A,Folch J

更新日期：2008-03-01 00:00:00

abstract：:The notion that maternal personality characteristics influence cognitive development in their children has been grounded in stress moderation theory. Maternal personality traits, such as self-esteem, may buffer maternal stressors or lead to improved maternal-child interactions that directly impact neurodevelopment. Th...

journal_title：Neurotoxicology

authors： Surkan PJ,Schnaas L,Wright RJ,Téllez-Rojo MM,Lamadrid-Figueroa H,Hu H,Hernández-Avila M,Bellinger DC,Schwartz J,Perroni E,Wright RO

更新日期：2008-03-01 00:00:00

abstract：:The effects of N-methyl carbamate pesticides on the photic after discharge (PhAD) of flash evoked potentials (FEPs) and the relationship between inhibition of brain cholinesterase (ChE) activity and the PhAD were evaluated. FEPs were recorded in Long Evans rats treated with physostigmine (s.c.) 0, 0.05, 0.1, 0.2 or 0....

journal_title：Neurotoxicology

authors： Mwanza JC,Finley D,Spivey CL,Graff JE,Herr DW

更新日期：2008-01-01 00:00:00

abstract：:The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating acetylcholinesterase and in eliminating oxidative stress induced by acute exposure to malathion was evaluated in mouse prefrontal cortex using in vivo methods. Malathion (1g/kg, dissolved in saline) was administered subcutaneou...

journal_title：Neurotoxicology

authors： da Silva AP,Farina M,Franco JL,Dafre AL,Kassa J,Kuca K

更新日期：2008-01-01 00:00:00

abstract：:Aluminum is a metal with known neurotoxic properties which are linked to encephalopathy and neurodegenerative diseases. The objectives of the current meta-analysis study were: (1) to summarize neurobehavioral data obtained by epidemiological studies in occupational settings and (2) to analyze confounding within these ...

journal_title：Neurotoxicology

authors： Meyer-Baron M,Schäper M,Knapp G,van Thriel C

更新日期：2007-11-01 00:00:00

abstract：:The popular recreational drug, 3,4-methylenedioxymethamphetamine (MDMA) is often taken as intermittent binges by adolescents at dance clubs. The neurobiological mechanisms that underlie MDMA-induced psychiatric conditions are still poorly understood. In the present study, mimicking adolescent patterns of administratio...

journal_title：Neurotoxicology

authors： Kindlundh-Högberg AM,Schiöth HB,Svenningsson P

更新日期：2007-11-01 00:00:00

abstract：:PC12 cells are an established model for studying the role of N-methyl-d-aspartate (NMDA) receptors in excitotoxicity and function as multimeric assemblies of NR1 with at least one NR2(A-D) subunit. We examined NR1 splice variant and NR2 subunit expression in four PC12 cell-lines (ATCC, WEHI, Ordway and Flinders), corr...

journal_title：Neurotoxicology

authors： Edwards MA,Loxley RA,Williams AJ,Connor M,Phillips JK

更新日期：2007-07-01 00:00:00

abstract：:This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...

journal_title：Neurotoxicology

authors： Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

更新日期：2007-05-01 00:00:00

abstract：:The purpose the present study was to determine if tolerance is developed to all behavioural effects produced by a single high dose of chlorpyrifos (CPF). For this, the study was divided in two phases; in the first phase, we studied the time course of the effects produced by treatment with a high dose of CPF (250 mg/kg...

journal_title：Neurotoxicology

authors： López-Crespo GA,Carvajal F,Flores P,Sánchez-Santed F,Sánchez-Amate MC

更新日期：2007-05-01 00:00:00

abstract：:Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case o...

journal_title：Neurotoxicology

authors： De Santis M,Straface G,Cavaliere AF,Rosati P,Batocchi AP,Caruso A

更新日期：2007-05-01 00:00:00

abstract：:Lead (Pb(2+)) is a pollutant commonly found in the environment. It causes a wide variety of detrimental effects on developing central nervous system. However, the mechanisms of its neurotoxicity remained to be elucidated. In hippocampus, the muscarinic cholinergic system modulates certain forms of synaptic transmissio...

journal_title：Neurotoxicology

authors： Wang L,Luo L,Luo YY,Gu Y,Ruan DY

更新日期：2007-05-01 00:00:00

abstract：:This study investigated the relationship between neurobehavioral performance and pulmonary function in young and middle adults. Data were collected from 178 subjects (88 male, 90 female) aged 20-50 years. Neurobehavioral performance was assessed by the Korean version of The Swedish Performance Evaluation System (SPES-...

journal_title：Neurotoxicology

authors： Min JY,Min KB,Paek D,Sakong J,Cho SI

更新日期：2007-03-01 00:00:00

abstract：:Questionnaires are one of the most common methodologies used in research on neurobehavioural effects in occupational and environmental health, most commonly for gathering information on demographic characteristics, psychological or neurological symptoms, mood state, or exposure to hazards. Questionnaires are self-repo...

journal_title：Neurotoxicology

authors： Williamson A

更新日期：2007-03-01 00:00:00

abstract：:1-Bromopropane (1-BP) has been widely used as a substitute for chlorofluorocarbon that destroys the ozone layer. Although the central neurotoxicity of 1-BP has been recently reported, a molecular mechanism is not clear. In particular, the effects on cells in brain have not been fully analyzed. Here, we studied the eff...

journal_title：Neurotoxicology

authors： Yoshida Y,Liu JQ,Nakano Y,Ueno S,Ohmori S,Fueta Y,Ishidao T,Kunugita N,Yamashita U,Hori H

更新日期：2007-03-01 00:00:00

abstract：:Among the several converging factors leading to Parkinson's disease, epidemiological studies indicate a correlation between Parkinson's disease (PD) with living in a rural area and/or exposure to agricultural pesticides. In this present study, we examined the potential of multiple agricultural pesticides for their abi...

journal_title：Neurotoxicology

authors： Leiphon LJ,Picklo MJ Sr

更新日期：2007-01-01 00:00:00

abstract：:Methylmercury (MeHg) toxicity in humans manifests deficits in neurological function. Cases of prenatal exposure to mercury have established that the developing nervous system is most highly susceptible to perturbation by MeHg. At a cellular level, MeHg-induced defects result from altered neuronal proliferation, migrat...

journal_title：Neurotoxicology

authors： Bland C,Rand MD

更新日期：2006-12-01 00:00:00

abstract：:Methyl mercury (MeHg) is highly toxic to the developing nervous system. Human exposure is mainly from fish consumption since small amounts are present in all fish. Findings of developmental neurotoxicity following high-level prenatal exposure to MeHg raised the question of whether children whose mothers consumed fish ...

journal_title：Neurotoxicology

authors： van Wijngaarden E,Beck C,Shamlaye CF,Cernichiari E,Davidson PW,Myers GJ,Clarkson TW

更新日期：2006-09-01 00:00:00

abstract：:There are reports suggesting that some autistic children are unable to mount an adequate response following exposure to environmental toxins. This potential deficit, coupled with the similarity in clinical presentations of autism and some heavy metal toxicities, has led to the suggestion that heavy metal poisoning mig...

journal_title：Neurotoxicology

authors： Walker SJ,Segal J,Aschner M

更新日期：2006-09-01 00:00:00